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Bilirubin

Bilirubin is found in all red-blooded animals. It is a natural by-product of the breakdown of hemoglobin, itself a by-product of normal red blood cell turnover. It is metabolized in the liver and is the principle pigment in bile.

The normally functioning liver removes bilirubin from the blood and reincorporates it into bile stored in the gall bladder. In the malfunctioning liver this function may be impaired causing higher than normal levels of bilirubin in the blood stream (serum bilirubin). Liver function tests commonly use diagnostic bilirubin as a standard preparation to compare with serum bilirubin levels and measure liver function.

In recent years several studies on the biochemical properties of bilirubin present strong evidence that the compound plays a beneficial role in the body, particularly as an endogenous (naturally generated within the body) antioxidant. Antioxidants are part of the human bodies natural defense system, which operates to scavenge and quench destructive oxygen radicals. The in vitro antioxidant properties of bilirubin were delineated largely by Stocker and co-workers in the late 1980’s.

Bilirubin supplementation provides health benefit to persons at risk of heart attack including smokers. Bilirubin has been shown reduce the oxidation of Low Density Lipoprotein (LDL), which has been implicated in plaque formation within blood vessels leading to heart disease. Frei et al found that bilirubin was more effective than other endogenous antioxidants, at protecting lipids from peroxyl radicals. A recent United States study examined the association between cigarette smokers and serum bilirubin antioxidant concentration. The study shoved that smoking is associated with a decrease in serum bilirubin concentration. This decrease in serum bilirubin may be associated with an increased incidence of heart attack in smokers.

Bilirubin sold in four different forms such as

	Active Pharmaceutical Ingredient up to99% + purity
	Medical Diagnostic Standard 99% + purity
	Ox Gallstone (bezoar) up to 50% purity (naturally produced)
	Manufactured (or artificial) bezoar usually 35% - 50% purity

Bio Pharma Pty Ltd, extract and purify commercial quantities of bilirubin from cattle and pig bile. Bulk bilirubin will be sold in 0.5kg, 1kg and 2kg dark plastic airtight and security sealed containers.

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Biliverdin

Biliverdin is a new product on our list and will be available very soon. Please ask for specification.

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P.O.Box 194,  Coopers Plains QLD 4108    Australia

E-mail: office@biopharma.com.au